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Previous to starting therapy with EPIDIOLEX, acquire serum transaminases (ALT and AST) and whole bilirubin levels. Serum transaminases and total bilirubin levels must be obtained at 1 month, 3 months, and 6 months after initiation of therapy with EPIDIOLEX, and periodically thereafter or as clinically indicated. Serum transaminases and whole bilirubin ranges must also be obtained inside 1 month following modifications in EPIDIOLEX dosage and addition of or changes in medications which are identified to impact the liver. Take into account extra frequent monitoring of serum transaminases and bilirubin in patients who're taking valproate or who've elevated liver enzymes at baseline.
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